Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI problems due to the inhibition of your synthesis of gastroprotective brokers like PGE2 as well as other prostaglandins. This inhibition causes lowered mucin production by gastric epithelial cells, fewer bicarbonate secretion, and fewer epithelial mobile turnover, amid other steps. https://muhammady357rsu0.wikilentillas.com/user