two. Histamine Receptor Antagonism: Some sedatives, for instance antihistamines, exert their sedative effects by blocking histamine receptors inside the brain, specifically H1 receptors. Histamine plays a role in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness. Opioids are Particularly at risk of turning into addictive and https://lanejevkz.blogkoo.com/history-of-sedative-drugs-their-evolution-in-medicine-52525208