No refrigeration is important, so keep it in the easy spot to suit your needs. These probiotics are microorganisms helpful to the Puppy’s digestive tract, that means this spray is all-all-natural. These microorganisms perform by improving the good bacteria which have been presently current within the Pet dog’s digestive tract. https://www.amazon.com/Healthy-Treatz-Probiotic-Chews-Dogs/dp/B07VCGNM6X